Ortho Science BYTES Podcast
Do antibodies to COVID-19 disappear? A conversation with Dr. Akiko Iwasaki

Do antibodies to COVID-19 disappear? A conversation with Dr. Akiko Iwasaki

November 18, 2020

In this podcast episode, Dr. Akiko Iwasaki discusses the type of immune response developed in a person with COVID-19 as well as the role of the antibodies in the course of the pandemic and how the antibody tests can contribute to its management. 

 

About our Speaker: Dr. Akiko Iwasaki received her Ph.D. from the University of Toronto (Canada) in 1998, and her postdoctoral training from the National Institutes of Health (USA) (1998-2000). She joined Yale University (USA) as a faculty in 2000, and currently is the Waldemar Von Zedtwitz Professor in the Department of Immunobiology and a Professor in the Department of Molecular, Cellular, and Developmental Biology at Yale University. She is also a principal investigator at the Howard Hughes Medical Institute. Her research interests among others include innate immunity, T cell immunity and her research focuses on the mechanisms of immune defense against viruses at the mucosal surfaces. Her laboratory is interested in how innate recognition of viral infections lead to the generation of adaptive immunity, and how adaptive immunity mediates protection against subsequent viral challenge. Most recently, Dr. Iwasaki has delved into research looking at the immune response of COVID-19 patients and sex differences in SARS-CoV-2 infection. 

 

READING MATERIALS:

• The New York Times. Your Coronavirus Antibodies Are Disappearing. Should You Care? July 27th/2020 https://nyti.ms/30U14v0 
• The New York Times. Scared that COVID-19 Immunity won’t last? Don’t be. July 31st/2020 https://nyti.ms/2Pb6Dj1 

What We Know About COVID-19 and Immunity

What We Know About COVID-19 and Immunity

October 28, 2020

Do antibodies really provide immunity against COVID-19? Are serological tests available today reliable enough to guide such critical decisions? In this episode, we will explore in detail the answers to those questions based on currently available scientific information.

 

About our Speaker: 

Dr. Fernando Chaves, MD, serves as the global head of medical, clinical, and scientific affairs for Ortho Clinical Diagnostics. In his role, Dr. Chaves is responsible for clinical trials, new product development, and key opinion leader relationships.

Dr. Chaves is a board-certified anatomical and clinical pathologist, with further certification in hematopathology, combining 5+ years of executive-level leadership with 10+ years of simultaneous diagnostic industry achievements and clinical hematopathology experience. He is a pioneering researcher and executive credited with discovering, testing, and bringing to market new laboratory tests for multiple medical conditions, predominantly sepsis-related and hematologic diseases. Dr. Chaves is recognized as an expert leader in the diagnostic industry with a passion for helping medical companies develop products that are immediately beneficial to patients in the most economical, efficient manner

The Association Between Blood Type and COVID-19

The Association Between Blood Type and COVID-19

September 10, 2020

In this episode of Ortho Science BYTES, speaker Tony Casina reviews the history of the association between blood type and development of diseases and whether literature answers the question if there are certain blood types associated with COVID-19.

 

About our Speaker: 

Tony S. Casina, MT(ASCP)SBB has worked in the blood banking industry for over 40 years with much of it in the commercial blood bank reagent manufacturers sector with hospital experience as a medical technologist and blood bank manager. Tony has provided technical support to laboratories throughout the world utilizing Ortho’s reagents and immunohematology test systems.  He has tested some of the most challenging antibody problems as part of his reference laboratory experience. Tony has been an active participant in the AABB serving on committees and currently on the AABB Board of Directors. He has contributed as a presenter to AABB and regional blood bank meetings educational programs. He was extensively involved in the development of the ORTHO VISION® Analyzer Platform.

 

References and Links: 

  • https://www.redcrossblood.org/donate-blood/blood-types.html 
  • Beyond immunohaematology: The role of the ABO blood group in human diseases, Giancarlo Maria Liumbruno & Massimo Franchini, Blood Transfus 2013; 11: 491-9, doi 10.2450/2013.0152-13. 
  • Annals of Hematology. Blood type and outcomes in patients with COVID-19. Christopher A. Latz, Charles DeCarlo, Laura Boitano, C. Y. Maximilian Png, Rushad Patell, & Mark F. July 2020 
  • The New England Journal of Medicine. Genomewide Association Study of Severe Covid-19 with Respiratory Failure. The Severe Covid-19 GWAS Group* Dr. Ellinghaus, Ms. Degenhardt, Drs. Valenti, Franke, Karlsen. June 17, 2020
  • Garratty G. Blood groups and disease: a historical perspective. Transfus Med Rev 2000; 14: 291-301.
Why Convalescent Plasma for COVID-19

Why Convalescent Plasma for COVID-19

July 30, 2020

Why Convalescent Plasma for COVID-19?

 

In this episode of Ortho Science BYTES host, Matt Dawson discuss why COVID-19 Convalescent Plasma has been used as a treatment and what are the scientific and clinical basis for its use with Dr. Lily Li.  

 

About our Speaker: 

Dr. Lily Li is the Medical Safety Officer at Ortho Clinical Diagnostics responsible for evaluating potential medical risks and guiding risk mitigation of all marketed products. She also serves as a Medical Director at Medical and Scientific Affairs providing evidence-based support to Ortho’s current and future products. Prior to joining Ortho, Lily had ten years of pharmaceutical R&D experience in Johnson & Johnson and led and advanced multiple programs of biologics and cell therapies through development. Lily obtained her Medical Degree from Peking University, China, and her Ph.D. in Immunology from the University of Alberta, Canada. She completed her post-doctoral training at the Scripps Research Institutes, San Diego. Lily is the author of more than 40 scientific articles and has filed 17 patent applications.

 

References and Links: 

  • Treatment of 5 Critically Ill Patients With COVID-19 With Convalescent Plasma; Shen at al. JAMA. 2020;323(16):1582-1589. Published online March 27, 2020.
  • The feasibility of convalescent plasma therapy in severe COVID-19 patients: a pilot study, Duan et al, Mar 2020, medRxiv preprint doi: https://doi.org/10.1101/2020.03.16.20036145
  • Effect of Convalescent Plasma Therapy on Time to Clinical Improvement in Patients With Severe and Life-threatening COVID-19: A Randomized Clinical Trial, Li et al, JAMA, 2020 Jun 3. doi: 10.1001/jama.2020.10044.
  • Convalescent plasma treatment of severe COVID-19: A matched 1 control study, S. T. H. Liu, et al, May 22, 2020, medRxiv preprint doi: https://doi.org/10.1101/2020.05.20.20102236.
  • Convalescent Plasma to Treat COVID-19. Possibilities and Challenges; John D. Roback, MD, PhD; Jeannette Guarner, MD. JAMA April 28, 2020 Volume 323, Number 16
  • The convalescent sera option for containing COVID-19 Arturo Casadevall, Liise-anne Pirofski. J Clin Invest. 2020;130(4):1545-1548.
     FDA site https://www.fda.gov/
You, a Blood Donor: Be part of 200 years of Transfusion Medicine’s History

You, a Blood Donor: Be part of 200 years of Transfusion Medicine’s History

July 30, 2020

You, a Blood Donor: Be part of 200 years of Transfusion Medicine’s History

 

In this short program, entitled "You, a Blood Donor: Be part of 200 years of Transfusion Medicine’s History," our own Tony Casina, Transfusion Medicine Consultant, takes us through key milestones in the History of Transfusion Medicine and brings us to today and how the community met the challenge to maintain a safe and adequate blood supply during the COVID-19 pandemic. 
 

Listen in as he discusses the honorable role of a donor of blood products, which can save up to three lives, and thanks the heroes who make this happen.

 

About our Speaker: 

Tony S. Casina, MT(ASCP)SBB has worked in the blood banking industry for over 40 years with much of it in the commercial blood bank reagent manufacturers sector with hospital experience as a medical technologist and blood bank manager. Tony has provided technical support to laboratories throughout the world utilizing Ortho’s reagents and immunohematology test systems.  He has tested some of the most challenging antibody problems as part of his reference laboratory experience. Tony has been an active participant in the AABB serving on committees and currently on the AABB Board of Directors. He has contributed as a presenter to AABB and regional blood bank meetings educational programs. He was extensively involved in the development of the ORTHO VISION® Analyzer Platform

 

References and Links: 

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